And the winner of the top prize at Research Expo 2013...the Rudee Outstanding Poster Award ...(drum roll)
Poster #182: A BIOMIMETIC NANOSPONGE AGAINST PORE-FORMING TOXINS
Student: Ronnie Hongbo Fang
Professor:
Liangfang
Zhang from the Department of NanoEngineering
Abstract
Many threats to public health, including bacterial infections and biological weaponry, often rely on pore-forming toxins for their virulence. Anti-virulence therapy, which targets these toxins, offers a way to detoxify the body and attenuate the effectiveness of the underlying threat. Existing platforms, including anti-sera, monoclonal antibodies, and molecularly imprinted polymers, have all been used effectively for this purpose, but they all require customized synthesis schemes for application against each individual type of toxin. We have developed a biomimetic toxin nanosponge targets the action mechanism of pore-forming toxins, and thus is applicable for the detoxification of a wide array of toxin types without the need for customized synthesis. The nanosponge is made by coating red blood cell membranes onto the surface of polymeric nanoparticle cores, and acts by absorbing membrane-damaging toxins and diverting them away from their intended targets. Using a murine model, it was demonstrated that these nanosponges are able to significantly increase the survival of mice challenged with a lethal dose of staphylococcal alpha-hemolysin (α-toxin). This rationally designed, bioinspired platform has the potential to be used as a treatment against a variety of diseases that employ pore-forming toxins.
Best Posters by Department
Bioengineering Best Poster
#11 ISOLATIONOF DNA FROM BLOOD SAMPLES FOR CANCER DIAGNOSTICS
Avery R. Sonnenberg
(Professor: Michael Heller)
Computer Science best poster
#31 CODESPELLS:LEARNING TO PROGRAM THROUGH IMMERSIVE GAMEPLAY
Sarah Marie Esper
Stephen Foster
(Professors:
William G. Griswold, Elizabeth A. Simon)
Electrical and Computer Engineering Best Poster
#77 PASSIVEACOUSTIC TRACKING OF TOOTHED WHALES WITH VOLUMETRIC SMALL-APERTURE ARRAYS
Martin Gassmann
(Professors:
John A. Hildebrand, William S. Hodgkiss, Gert Lanckriet )
Katie Osterday Best
Poster
Mechanical and Aerospace Engineering
Amanpreet Kaur
(Professor:
Carlos F. Coimbra)
NanoEngineering Best Poster
#182 A BIOMIMETIC NANOSPONGE AGAINST PORE-FORMING TOXINS
Ronnie Hongbo Fang
(Professor:
Liangfang
Zhang)
Structural Engineering
#200 CEMENT
SEA-WATER BATTERY (C-SWB) POWERED SENSOR NODE FOR MARINE INFRASTRUCTURE
MONITORING
Scott Anthony
Ouellette
(Professor:
Michael D. Todd)
*New for 2013*
von Liebig Entrepreneurism Center Innovation Awards
von
Liebig Entrepreneurism Center
Innovation Award in
Information Technology
#46 SOPRA
– A PROACTIVE SERVICE ORIENTED SELF-ADAPTIVE FRAMEWORK FOR DATA CENTER RESOURCE
OPTIMIZATION
Filippo Seracini
(Professor:
Ingolf
Krueger)
von
Liebig Entrepreneurism Center
Innovation Award in
Life Sciences
#183 ANTIMICROBIAL
NANOTHERAPEUTICS FOR THE TREATMENT OF H. PYLORI INFECTION
Soracha Thamphiwatana
Victoria Fu
(Professor: Liangfang Zhang)
von
Liebig Entrepreneurism Center
Innovation Award in
Materials Mechanics or Energy
#118 ADVANCES
IN INTRA-DAY SOLAR FORECASTING TECHNOLOGIES
Lukas Nonnenmacher
(Professor:
Carlos F. Coimbra)
***
Best Poster Awards: Honorable Mentions by Department
Bioengineering
Honorable Mention Posters
#17 REGULATION OF MITOCHONDRIAL METABOLISM
BY THE LKB1 TUMOR SUPPRESSOR Student: Seth Jameson Parker
Professor: Christian M. Metallo
#21 QUANTITATIVE TRANSCRIPTOMICS USING
DESIGNED PRIMER-BASED AMPLIFICATION
Student: Vipul Bhargava
Professor: Shankar Subramaniam
Computer Science and
Engineering Honorable Mention Posters
#28 RECOGNIZING SIGHTS, SMELLS, AND SOUNDS
WITH GNOSTIC FIELDS
Student: Christopher Kanan
Professor: Garrison W. Cottrell
#50 HOMESIM: COMPREHENSIVE, SMART,
RESIDENTIAL ENERGY SIMULATION AND SCHEDULING
Students: Jagannathan Venkatesh, Alper Akyurek
Professor: Tajana S. Rosing
#51 TEMPERATURE AWARE THREAD BLOCK
SCHEDULING FOR GPGPUS
Student: Rajib Kumar Nath
Professor: Tajana S. Rosing
Electrical and
Computer Engineering Honorable Mention Posters
#60 HIGH ENERGY DENSITY, HIGH OPERATING
FREQUENCY AND ENERGY EFFICIENT ON-CHIP INDUCTORS BASED ON COILED CARBON
NANOTUBES (CCNTS)
Student: Hasan Mohammad Faraby
Professor: Prabhakar R. Bandaru
#70 NANOSCALE PLASMONIC DEVICES FOR
BIOSENSING APPLICATIONS
Students: Lindsay Michelle Freeman, Lin
Pang, Brandon Hong, Alexei Smolyaninov
Professor: Y. Shaya Fainman
#74 WIDE-FIELD OF VIEW FIBER-COUPLED
MONOCENTRIC IMAGERS
Student: Igor Stamenov
Professor: Joseph E. Ford
#82 POST-ROUTING LAYOUT OPTIMIZATIONS FOR
IMPROVED TIME-DEPENDENT DIELECTRIC BREAKDOWN RELIABILITY IN SUB-20NM ICS
Student: Tuck Boon Chan
Professor: Andrew B. Kahng
#86 NANOPATTERNED MULTILAYER HYPERBOLIC
METAMATERIALS FOR SPONTANEOUS LIGHT EMISSION CONTROL
Students: Danyong Lu,
Lorenzo Ferrari, Jimmy Kan
Professors: Zhaowei
Liu, Eric Fullerton
#97 ASSISTING THE DRIVER DURING CHALLENGING
MANEUVERS USING PROBABILISTIC MODELING AND INTEGRATED SENSING
Student: Sayanan Vinoth Sivaraman
Professor: Mohan M. Trivedi
#100 MONITORING HEAD DYNAMICS FOR DRIVER
ASSISTANCE SYSTEMS: A MULTI-PERSPECTIVE APPROACH
Student: Sujitha Catherine Martin
Professor: Mohan M. Trivedi
#102 GROWTH WINDOW AND OPTICAL PROPERTIES OF
GAP/GANP CORE/SHELL NANOWIRE ARRAYS
Student: Supanee Sukrittanon
Professor: Charles W. Tu
Mechanical and
Aerospace Engineering Honorable Mention Posters
#111 FAST ELECTRON TRANSPORT AND SPATIAL
ENERGY DEPOSITION INTO IMPLODED HIGH DENSITY PLASMAS USING CU-DOPED CD SHELL
TARGETS
Student: Leonard C. Jarrott
Professor: Farhat N.
Beg
#114 STUDY OF PRE-PLASMA EFFECTS ON FAST
ELECTRON GENERATION AND TRANSPORT USING THE 1.5 KJ, 10 PS OMEGA EP LASER WITH
BREMSSTRAHLUNG SPECTROMETERS
Student: Jonathan Lee Peebles
Professor: Farhat N.
Beg
#123 TEAM-TRIGGERED COORDINATION OF ROBOTIC
NETWORKS
Student: Cameron Nowzari
Professor: Jorge Cortes
#128 MECHANO-CHEMICAL MODEL OF CANCER CELL
INVASION
Student: Jui-Hsien Wang
Professor: Juan Carlos Del Alamo
#129 PARTICLE TRACKING MICRORHEOLOGY OF
VISCOUS NEMATIC GELS
Student: Manuel Gomez-Gonzalez
Professor: Juan Carlos Del Alamo
#130 LAGRANGIAN COHERENT STRUCTURES IN
TURBULENT SEPARATED FLOW
Student: Daniel A. Nelson
Professors: Gustaaf Jacobs, Sutanu Sarkar
#131 SKY IMAGER SOLAR FORECASTING FOR
MICROGRID OPTIMIZATION
Students: Benjamin Bernard Kurtz, Bryan
Urquhart, Chi Wai Chow, Anders Nottrot, Mohamed Ghonima, Andu
Nguyen, Handa
Yang, Oytun Babacan
Professor: Jan P. Kleissl
#138 MAGNETIC FREEZE CASTING INSPIRED BY
NATURE
Student: Michael Martin Porter
Professors: Joanna M. McKittrick,
Marc A. Meyers
NanoEngineering
Honorable Mention Posters
#161 BIOCOMPATIBLE COATING FOR IMPROVED IN
VIVO PERSISTENCE OF ADENOVIRUSES Student: Gen Yong
Professor: Sadik C. Esener
#174 DESIGN OF A SOLAR THERMOCHEMICAL
HYDROGEN PRODUCTION PLANT
Student: Wesley Wai Luc
Professors: Jan B. Talbot, Richard K. Herz
Structural Engineering
Honorable Mention Posters
#194 SHAKE TABLE TESTING OF A FULL-SCALE
FIVE-STORY BUILDING: SEISMIC PERFORMANCE OF PRECAST CONCRETE CLADDING PANELS
Student: Elide Pantoli
Professor: Tara C. Hutchinson
#201 IMPROVED SENSITIVITY OF CONDITION
MONITORING FEATURES VIA HOLDER EXPONENT ANALYSIS
Student: Luke Thomas Robinson
Professors: Michael D. Todd, Charles R.
Farrar
S&E Library Best
Literature Review Awards
#183 ANTIMICROBIAL NANOTHERAPEUTICS FOR THE
TREATMENT OF H. PYLORI INFECTION
Students: Soracha Thamphiwatana,
Victoria Fu
Professor: Liangfang
Zhang
#195 SHAKE TABLE TESTING OF STIFF MODEL
STATUE STRUCTURES CONSIDERING MASS ECCENTRICITY
Student: Christine Wittich
Professor: Tara C. Hutchinson