Poster #182: A BIOMIMETIC NANOSPONGE AGAINST PORE-FORMING TOXINS
Student: Ronnie Hongbo Fang
Professor:
Liangfang
Zhang from the Department of NanoEngineering
Abstract
Many threats to public health, including bacterial infections and biological weaponry, often rely on pore-forming toxins for their virulence. Anti-virulence therapy, which targets these toxins, offers a way to detoxify the body and attenuate the effectiveness of the underlying threat. Existing platforms, including anti-sera, monoclonal antibodies, and molecularly imprinted polymers, have all been used effectively for this purpose, but they all require customized synthesis schemes for application against each individual type of toxin. We have developed a biomimetic toxin nanosponge targets the action mechanism of pore-forming toxins, and thus is applicable for the detoxification of a wide array of toxin types without the need for customized synthesis. The nanosponge is made by coating red blood cell membranes onto the surface of polymeric nanoparticle cores, and acts by absorbing membrane-damaging toxins and diverting them away from their intended targets. Using a murine model, it was demonstrated that these nanosponges are able to significantly increase the survival of mice challenged with a lethal dose of staphylococcal alpha-hemolysin (α-toxin). This rationally designed, bioinspired platform has the potential to be used as a treatment against a variety of diseases that employ pore-forming toxins.
Many threats to public health, including bacterial infections and biological weaponry, often rely on pore-forming toxins for their virulence. Anti-virulence therapy, which targets these toxins, offers a way to detoxify the body and attenuate the effectiveness of the underlying threat. Existing platforms, including anti-sera, monoclonal antibodies, and molecularly imprinted polymers, have all been used effectively for this purpose, but they all require customized synthesis schemes for application against each individual type of toxin. We have developed a biomimetic toxin nanosponge targets the action mechanism of pore-forming toxins, and thus is applicable for the detoxification of a wide array of toxin types without the need for customized synthesis. The nanosponge is made by coating red blood cell membranes onto the surface of polymeric nanoparticle cores, and acts by absorbing membrane-damaging toxins and diverting them away from their intended targets. Using a murine model, it was demonstrated that these nanosponges are able to significantly increase the survival of mice challenged with a lethal dose of staphylococcal alpha-hemolysin (α-toxin). This rationally designed, bioinspired platform has the potential to be used as a treatment against a variety of diseases that employ pore-forming toxins.
Parts of this work were published last week in Nature Nanotechnology. Check out the Jacobs School press release on related work.
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