Thursday, April 18, 2013

Research Expo 2013 Winners

And the winner of the top prize at Research Expo 2013...the Rudee Outstanding Poster Award ...(drum roll)

Poster #182: A BIOMIMETIC NANOSPONGE AGAINST PORE-FORMING TOXINS 
Student: Ronnie Hongbo Fang
Professor: Liangfang Zhang from the Department of NanoEngineering

Abstract
Many threats to public health, including bacterial infections and biological weaponry, often rely on pore-forming toxins for their virulence. Anti-virulence therapy, which targets these toxins, offers a way to detoxify the body and attenuate the effectiveness of the underlying threat. Existing platforms, including anti-sera, monoclonal antibodies, and molecularly imprinted polymers, have all been used effectively for this purpose, but they all require customized synthesis schemes for application against each individual type of toxin. We have developed a biomimetic toxin nanosponge targets the action mechanism of pore-forming toxins, and thus is applicable for the detoxification of a wide array of toxin types without the need for customized synthesis. The nanosponge is made by coating red blood cell membranes onto the surface of polymeric nanoparticle cores, and acts by absorbing membrane-damaging toxins and diverting them away from their intended targets. Using a murine model, it was demonstrated that these nanosponges are able to significantly increase the survival of mice challenged with a lethal dose of staphylococcal alpha-hemolysin (α-toxin). This rationally designed, bioinspired platform has the potential to be used as a treatment against a variety of diseases that employ pore-forming toxins.

Parts of this work were published last week in Nature Nanotechnology. Check out the Jacobs School press release on related work.





Best Posters by Department

Bioengineering Best Poster
#11 ISOLATIONOF DNA FROM BLOOD SAMPLES FOR CANCER DIAGNOSTICS
Avery R. Sonnenberg
(Professor: Michael Heller)


Computer Science best poster
#31 CODESPELLS:LEARNING TO PROGRAM THROUGH IMMERSIVE GAMEPLAY
Sarah Marie Esper
Stephen Foster
(Professors: William G. Griswold, Elizabeth A. Simon) 

Electrical and Computer Engineering Best Poster
#77 PASSIVEACOUSTIC TRACKING OF TOOTHED WHALES WITH VOLUMETRIC SMALL-APERTURE ARRAYS
Martin Gassmann
(Professors: John A. Hildebrand, William S. Hodgkiss, Gert Lanckriet )

Katie Osterday Best Poster
Mechanical and Aerospace Engineering
Amanpreet Kaur
(Professor: Carlos F. Coimbra) 

NanoEngineering Best Poster
#182  
A BIOMIMETIC NANOSPONGE AGAINST PORE-FORMING TOXINS
Ronnie Hongbo Fang
(Professor: Liangfang Zhang)

Structural Engineering
#200 CEMENT SEA-WATER BATTERY (C-SWB) POWERED SENSOR NODE FOR MARINE INFRASTRUCTURE MONITORING
Scott Anthony Ouellette
(Professor: Michael D. Todd) 

*New for 2013*
von Liebig Entrepreneurism Center Innovation Awards


von Liebig Entrepreneurism Center
Innovation Award in Information Technology

#46 SOPRA – A PROACTIVE SERVICE ORIENTED SELF-ADAPTIVE FRAMEWORK FOR DATA CENTER RESOURCE OPTIMIZATION
Filippo Seracini
(Professor: Ingolf Krueger)

von Liebig Entrepreneurism Center
Innovation Award in Life Sciences
#183 ANTIMICROBIAL NANOTHERAPEUTICS FOR THE TREATMENT OF H. PYLORI INFECTION
Soracha Thamphiwatana
Victoria Fu
(Professor: Liangfang Zhang)

von Liebig Entrepreneurism Center
Innovation Award in Materials Mechanics or Energy
#118 ADVANCES IN INTRA-DAY SOLAR FORECASTING TECHNOLOGIES
Lukas Nonnenmacher
(Professor: Carlos F. Coimbra)


***
Best Poster Awards: Honorable Mentions by Department

Bioengineering Honorable Mention Posters

#17 REGULATION OF MITOCHONDRIAL METABOLISM BY THE LKB1 TUMOR SUPPRESSOR Student: Seth Jameson Parker
Professor: Christian M. Metallo

#21 QUANTITATIVE TRANSCRIPTOMICS USING DESIGNED PRIMER-BASED AMPLIFICATION
Student: Vipul Bhargava
Professor: Shankar Subramaniam

Computer Science and Engineering Honorable Mention Posters

#28 RECOGNIZING SIGHTS, SMELLS, AND SOUNDS WITH GNOSTIC FIELDS
Student: Christopher Kanan
Professor: Garrison W. Cottrell

#50 HOMESIM: COMPREHENSIVE, SMART, RESIDENTIAL ENERGY SIMULATION AND SCHEDULING
Students: Jagannathan Venkatesh, Alper Akyurek
Professor: Tajana S. Rosing

#51 TEMPERATURE AWARE THREAD BLOCK SCHEDULING FOR GPGPUS
Student: Rajib Kumar Nath
Professor: Tajana S. Rosing


Electrical and Computer Engineering Honorable Mention Posters

#60 HIGH ENERGY DENSITY, HIGH OPERATING FREQUENCY AND ENERGY EFFICIENT ON-CHIP INDUCTORS BASED ON COILED CARBON NANOTUBES (CCNTS)
Student: Hasan Mohammad Faraby
Professor: Prabhakar R. Bandaru

#70 NANOSCALE PLASMONIC DEVICES FOR BIOSENSING APPLICATIONS
Students: Lindsay Michelle Freeman, Lin Pang, Brandon Hong, Alexei Smolyaninov
Professor: Y.
Shaya Fainman

#74 WIDE-FIELD OF VIEW FIBER-COUPLED MONOCENTRIC IMAGERS
Student: Igor Stamenov
Professor: Joseph E. Ford

#82 POST-ROUTING LAYOUT OPTIMIZATIONS FOR IMPROVED TIME-DEPENDENT DIELECTRIC BREAKDOWN RELIABILITY IN SUB-20NM ICS
Student: Tuck Boon Chan
Professor: Andrew B. Kahng

#86 NANOPATTERNED MULTILAYER HYPERBOLIC METAMATERIALS FOR SPONTANEOUS LIGHT EMISSION CONTROL
Students: Danyong Lu, Lorenzo Ferrari, Jimmy Kan
Professors: Zhaowei Liu, Eric Fullerton

#97 ASSISTING THE DRIVER DURING CHALLENGING MANEUVERS USING PROBABILISTIC MODELING AND INTEGRATED SENSING
Student: Sayanan Vinoth Sivaraman
Professor: Mohan M. Trivedi

#100 MONITORING HEAD DYNAMICS FOR DRIVER ASSISTANCE SYSTEMS: A MULTI-PERSPECTIVE APPROACH
Student: Sujitha Catherine Martin
Professor: Mohan M. Trivedi

#102 GROWTH WINDOW AND OPTICAL PROPERTIES OF GAP/GANP CORE/SHELL NANOWIRE ARRAYS
Student: Supanee Sukrittanon
Professor: Charles W. Tu

Mechanical and Aerospace Engineering Honorable Mention Posters

#111 FAST ELECTRON TRANSPORT AND SPATIAL ENERGY DEPOSITION INTO IMPLODED HIGH DENSITY PLASMAS USING CU-DOPED CD SHELL TARGETS
Student: Leonard C. Jarrott
Professor: Farhat N. Beg

#114 STUDY OF PRE-PLASMA EFFECTS ON FAST ELECTRON GENERATION AND TRANSPORT USING THE 1.5 KJ, 10 PS OMEGA EP LASER WITH BREMSSTRAHLUNG SPECTROMETERS
Student: Jonathan Lee Peebles
Professor: Farhat N. Beg

#123 TEAM-TRIGGERED COORDINATION OF ROBOTIC NETWORKS
Student: Cameron Nowzari
Professor: Jorge Cortes

#128 MECHANO-CHEMICAL MODEL OF CANCER CELL INVASION
Student: Jui-Hsien Wang
Professor: Juan Carlos Del Alamo

#129 PARTICLE TRACKING MICRORHEOLOGY OF VISCOUS NEMATIC GELS
Student: Manuel Gomez-Gonzalez
Professor: Juan Carlos Del Alamo

#130 LAGRANGIAN COHERENT STRUCTURES IN TURBULENT SEPARATED FLOW
Student: Daniel A. Nelson
 Professors: Gustaaf Jacobs, Sutanu Sarkar

#131 SKY IMAGER SOLAR FORECASTING FOR MICROGRID OPTIMIZATION
Students: Benjamin Bernard Kurtz, Bryan Urquhart, Chi Wai Chow, Anders Nottrot, Mohamed Ghonima, Andu Nguyen, Handa Yang, Oytun Babacan
Professor: Jan P. Kleissl

#138 MAGNETIC FREEZE CASTING INSPIRED BY NATURE
Student: Michael Martin Porter
Professors: Joanna M. McKittrick, Marc A. Meyers

NanoEngineering Honorable Mention Posters

#161 BIOCOMPATIBLE COATING FOR IMPROVED IN VIVO PERSISTENCE OF ADENOVIRUSES Student: Gen Yong
Professor: Sadik C. Esener

#174 DESIGN OF A SOLAR THERMOCHEMICAL HYDROGEN PRODUCTION PLANT
Student: Wesley Wai Luc
Professors: Jan B. Talbot, Richard K. Herz

Structural Engineering Honorable Mention Posters

#194 SHAKE TABLE TESTING OF A FULL-SCALE FIVE-STORY BUILDING: SEISMIC PERFORMANCE OF PRECAST CONCRETE CLADDING PANELS
Student: Elide Pantoli
Professor: Tara C. Hutchinson

#201 IMPROVED SENSITIVITY OF CONDITION MONITORING FEATURES VIA HOLDER EXPONENT ANALYSIS
Student: Luke Thomas Robinson
Professors: Michael D. Todd, Charles R. Farrar

S&E Library Best Literature Review Awards


#183 ANTIMICROBIAL NANOTHERAPEUTICS FOR THE TREATMENT OF H. PYLORI INFECTION
Students: Soracha Thamphiwatana, Victoria Fu
Professor: Liangfang Zhang

#195 SHAKE TABLE TESTING OF STIFF MODEL STATUE STRUCTURES CONSIDERING MASS ECCENTRICITY
Student: Christine Wittich
Professor: Tara C. Hutchinson

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